I’m running make.contigs on my local desktop (Mac Pro with 32G RAM). It always fails in the middle. But the job can be finished in my M1 Mac Air with 8G RAM. I found the memory usage is very different. When it runs on M1 Mac Air, the memory usage is about 400~500 MB. But in my Mac Pro (3.5 GHz 8-Core Intel Xeon W), it uses 200GB (most in SWAP) and was killed with error “Killed:9”. The version of mothur is 1.44.11 on both machine.