Easiest Linux OS for Mothur installation?

What is the easiest Linux OS to install Mothur on?

I’ve been trying to install Mothur on an older CentOS 5 (not 6) Linux box. Starting to worry about dependencies conflicting with other essential software packages so I just picked up an extra hard drive to streamline the process.

Just installed the newest version of Ubuntu. Took me a whopping 5 seconds to get mothur up and running in CLI mode.

Will have to try GUI out but this is 1,000 times easier to work with.